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Antigone Man-slayer - Guide, Masteries, GearEpic

Antigone Man-slayer — guide

Epic ArgonitesAlly: Nyresan UnionRole: HP Element: Void
Speed98
HP20805
Defense1112
Attack804
Author: RAID GURU Editorial Updated: 21.10.2026 Reading: ~1 min 0 reviews

Build

Artifact sets
SpeedRetaliationRegenerationImmortalPerceptionImpulseSupersonicPinpointMercurial
Key masteries
Energy ExpansionUnflinchingUncontrollableHeal 'N' Go
Blessings
Survival instinctMiracle HealCommanding PresenceCrueltyEmergency Heal
Relics
Journal of NecrotosHallowed HiltLifespring Skull
Best in
Spider's DenDragon's LairAgrethTainted SkavagTainted Hellrazor

The build is a guideline: the first sets in the list fit most often. Adapt it to your artifacts and goals.

Guide and skills

Antigone the Ruiner is an Epic champion in RAID: Shadow Legends from the Argonites faction (Nyresan Union), role — HP, affinity — Void.

Skills

SkillDescriptionLevel Upgrades

Mother's Instinct

Attacks an enemy.
Heals by 10% of this Champion's MAX HP. Heals all other allies by 5% of their MAX HP.
Damage based on [HP] = 0.24 × [HP]

Effects: Heals self, Heals allies

Lvl 2 Damage +5%
Lvl 3 Damage +5%
Lvl 4 Damage +5%
Lvl 5 Damage +5%

Island Warden

Cooldown: 4 turns

Attacks all enemies.
Has a 75% (100%) chance of placing a 25% [Weaken] debuff for 2 turns.
Also places a [Shield] buff on all allies for 2 turns equal to 20% of this Champion's MAX HP.
Damage based on [HP] = 0.25 × [HP] AoE

Effects: 25% Weaken, Shield

Lvl 2 Damage +10%
Lvl 3 Damage +10%
Lvl 4 Debuff chance: +10%
Lvl 5 Debuff chance: +15%
Lvl 6 Cooldown -1

Drop the Burden

Cooldown: 4 turns

Attacks an enemy. Before attacking, transfers all Poison and HP Burn debuffs, as well as one random debuff from all allies onto themselves. Does not transfer Stun, Sleep, Fear, True Fear, Provoke, Freeze, Frostbite, and Polymorph.
Transfers all debuffs from themselves onto the target.
Damage based on [HP] = 0.35 × [HP]

Effects: Transfers debuffs

Lvl 2 Damage +10%
Lvl 3 Damage +10%
Lvl 4 Cooldown -1

Shared Torment

Has a 25% chance of reflecting all Poison and HP Burn debuffs back to the attacking enemy. If under a Shield buff, this chance increases to 50%.
AuraIncreases Ally HP in Dungeons by 33%.

Where to get

Ancient Shardsmall chance
Sacred Shardhigh chance for an Epic
Void Shardonly Void affinity champions
Events and fusionsstay tuned

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Question — answer

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Video - Guide